SidaSubSaharaV1, Main, Exploration, bibRecord, 002237

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Identifieur interne : 002237 ( Main/Exploration ); précédent : 002236; suivant : 002238

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Auteurs : Koosha Paydary [Iran] ; Parisa Khaghani [Iran] ; Sahra Emamzadeh-Fard [Iran] ; Seyed Ahmad Seyed Alinaghi [Iran] ; Kazem Baesi [Iran]

Source :

Asian Pacific Journal of Tropical Biomedicine [ 2221-1691 ] ; 2013.

RBID : PMC:3695575

Abstract

After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world; however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695575

DOI: 10.1016/S2221-1691(13)60106-9
PubMed: 23835806
PubMed Central: 3695575

Affiliations:

Iran

Le document en format XML

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Le SIDA en Afrique subsaharienne (serveur d'exploration)

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Source :

Abstract

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